Cost-efficient polyurea carrier for precise control of an anti-inflammatory drug loading and release

In this paper, we present a cost-efficient and reliable route to produce polyurea xerogel (PolyU) as versatile carrier that provides high drug loading offers tuning over diclofenac (DCF) release profile. A simple one-pot reaction of an amino-terminated-polyether-PEO crosslinker, hexamethylene diisocyanate trimer-HDI, allow us obtain the polymeric networks. The gelation time during sol-gel reactions (hydrolysis condensation) can be modulated from minutes hours by using acetone solvent achieve decrease reactivity between amine groups PEO with isocyanate HDI crosslinker. interactions PolyU networks DCF was in depth evaluated Fourier Transform Infrared Spectroscopy (FTIR), small angle X-ray scattering (SAXS) computational studies. Analysis performed differential scanning calorimetry (DSC) have confirmed inhibition crystalline moities chains. investigated cell toxicity studies, showing no significant cytotoxicity against CHO–K1 line. Considering abundance raw materials for preparation, work clearly opens up prospects solution scaling fabrication new functional devices (contact lenses, patches, thin films, etc) broad applications medical/health fields.